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Once-daily memantine: pharmacokinetic and clinical considerations

Antioxidant systems such as superoxide dismutase, glutathione (GSH), glutaredoxin, heme oxygenase and thioredoxin (TRX) systems protect cells from the pathological effects of ROS

In addition, mouse BMECs were also found to produce inflammatory responses upon LPS stimulation, specifically by directly producing inflammatory factors such as interleukin (IL)-1, IL-18, IL-6, and TNF-, and these factors are able to mediate the damaging effects of LPS on the BBB (Smyth et al., 2018

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Among them, the HLA gene cluster is closely associated with susceptibility to AA, especially certain subtypes of HLADQ and HLADR, which increase the risk of developing the condition [149]

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