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Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway

Metabolites were identified by matching the EI spectra with those of reference compounds from the NIST or Fiehn libraries

Neuroeffector apparatus in gastrointestinal smooth muscle organs

10.1104/pp.105.066803 99 LuoM.LiangX

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Associated with this functional deficit, the hearts of the knockout mice are enlarged (hypertrophic) and present significant dysregulation in genes involved in cardiovascular disease, including genes critical for cardiac contractility (Ryr2