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these kinases are able to catalyze the phosphorylation of MAPKs, ERK1, and ERK2, thus rank-ordering the MAPK cascade from RAS, RAF, MEK, and finally to ERK [112, 113]

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Nevertheless, in vitro mitochondrial function was indistinguishable from wild-type 17

[1] Because of this variability, recent systematic reviews often conclude that evidence of efficacy is inconclusive or limited

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