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Since then, AOD-9604 has appeared across many lines of preclinical and early-phase clinical research focused on obesity, adipose biology, and articular cartilage models

[DOI] [PMC free article] [PubMed] [Google Scholar] Mller S, Mrz R, Schmolz M, Drewelow B, Eschmann K, Meiser P (2013) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain

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Extensive changes were also introduced to the Medication Guide