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Key mechanisms of action include: Fibroblast activation Suppression of collagen-degrading enzymes Reduced inflammatory cytokines Enhanced granulation tissue formation Improved angiogenesis In ischemic wound models, injectable GHK-Cu restored fibroblast function and significantly accelerated skin repair compared to controls

These bioactive constituents undergo in vivo biotransformation to glucuronide-sulfate conjugates, possessing multifaceted pharmacological properties including metabolic enhancement, antihypertensive effects, antioxidative stress amelioration, and anti-inflammatory activities, conferring crucial nephroprotective roles in DN, hypertensive nephropathy, glomerulonephritis, and LN (Chen et al., 2016

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An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats

TangXDingHLiangMChenXYanYWanNet alCurcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy

Acknowledgments The authors gratefully acknowledge Khalifa Center for Genetic Engineering and Biotechnology-UAEU (Grant number: 12R255), and the UAEU program of Advanced Research (Grant number: 12S169) for supporting this work