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It is curious that despite low cytoplasmic copper levels, CueO and PcoA exhibit a twin-arginine motif in their leader sequences, suggesting that they are translocated from the cytoplasm by the twin arginine translocation (Tat) pathway with copper-bound active sites (Huffman et al., 2002)

LL-37 is part of the innate immune system and influences: Antimicrobial defense Inflammatory signaling Immune modulation Skin healing Abnormal processing of LL-37 has been implicated in rosacea pathophysiology

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(2019) Lancet, 394: 1159.(367)Wang Y, et al

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A positive correlation was established for glutathione in the anterior cingulate cortex and social/occupational functioning