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BioMed Res Int 2020:112 Ackler S, Mitten MJ, Foster K, Oleksijew A, Refici M, Tahir SK, Xiao Y, Tse C, Frost DJ et al (2010) The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

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These aggregates compromise ADC pharmaceutical stability making them more susceptible to immune system clearance [22, 206, 207]