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(Created with biorender.com) Thus, it is questionable whether this mechanism can be applied to other cell types, particularly hepatocytes with their complex, multi-layered antioxidant systems

The results showed that decreased levels of SIRT1 impacted the activation of pRb, a crucial cell cycle protein, leading to a reduction in its phosphorylation and subsequent inactivation

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For instance, an increase in RO level is closely related to neuronal apoptosis, which impinges on the function and health of the nervous system, underscoring the need for further mechanistic studies [68]

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56 This could lead to tumor cell resistance to trastuzumab, anti-estrogen, doxorubicin and tamoxifen in BC and radiation in cervical cancer