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Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of IntegReview (protocol code #0220 and 02/26/2020)

This dosage is recognized for its ability to reliably decrease sperm quality and testosterone levels, and to induce histopathological changes in testicular tissue, making it a suitable positive control for evaluating the protective effects of potential therapeutic agents 40

The NLRP3 inflammasome is significantly upregulated in the colonic mucosa of patients with UC, and its activity correlates with disease progression (115)

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Then, -N-trimethyllysine enters mitochondria where it undergoes hydroxylation by the -N-trimethyllysine hydroxylase to produce -hydroxy-N--trimethyllysine, a process that requires vitamin C and iron as cofactors [12]