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Immunotherapy Individual RT has limited penetration depth and uneven dose distribution, resulting in a "blind spot" of residual live cancer cells and increasing the risk of tumor metastasis

Wang H, Li J, Follett PL, Zhang Y, Cotanche DA, Jensen FE et al

Kumagai, S

For acute OIPN, the dysfunction of ion channels, OCT protein, and glial cells are involved in the acute pain, whereas the main mechanisms relevant to chronic OIPN are nuclear DNA damage, oxidative stress-induced mitochondrial damage, glia activation-related neuroinflammation, and gut microbiota-induced inflammation (Fig

It is also critical in communication between the brain and muscles

2 to 3 Months and Beyond: Long-Term Support Some of the deeper benefits take longer because they involve slower repair processes, especially in the nervous system