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This triggers widespread inflammation, with trauma-induced mitochondrial DAMPs further intensifying oxidative stress and contributing to a sepsis-like state [22,25,26,27]

A general hypothetical model depicting the major ROS-driven pathways described in this review is illustrated in Figure 1

[DOI] [PMC free article] [PubMed] [Google Scholar] 275.Hu W., Macdonald M

10.1007/s00394-010-0102-2 30 DullA.-M.MogaM
Studies in clinical populations have shown that M6G has a more favourable profile than morphine with respect to nausea and vomiting [124, 125]

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