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These pharmacokinetic characteristics reflect ACs poor gastrointestinal absorption, high first-pass metabolism, and possible efflux by transporters such as P-gp, which together significantly limit its oral bioavailability and therapeutic translation

While this nanoparticle was featured with high TME-specificity and thus effectively induced cancer cell death (Zhang et al., 2022)

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The ER stress response is a cellular mechanism triggered by ER dysfunction, such as protein misfolding or calcium ion imbalance

Amplification of MYC results in its overexpression, promoting excessive cell proliferation and significantly contributing to tumor formation (Hasty and Montagna 2014)