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Compared with saline and free-drug controls, TBP-NP-treated mice demonstrated significantly improved range of motion and enhanced mechanical properties, confirming effective tendon-specific targeting and functional repair ( In vitro , PDGF-BB cmRNA enhanced tendon cell proliferation and migration, while IL1RA cmRNA reduced pro-inflammatory cytokine expression

System Xc- is a crucial transporter for cystine and glutamate, forming a heterodimeric complex with the subunits SLC7A11 and SLC3A2 (60)

In addition, dietary glycine supplementation increased GSH availability and led to metabolic benefits such as reduced body weight, adiposity, insulin resistance, oxidative stress markers, and mitochondrial function 17,18,20

The primary endpoint was change in HbA 1c (%-points) from baseline to week 68 with CagriSema 2.4 mg/2.4 mg versus semaglutide 2.4 mg

This anti-tumor effect may be achieved through mechanisms such as regulating the immune system, inhibiting tumor cell proliferation, and inducing tumor cell apoptosis

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