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(Felice Crocetto)
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In order to optimize physicochemical properties, increase on-target affinity and reduce instability and off-target neosubstrates, several research groups have developed novel non-phthalimide cereblon binders and incorporated them into the construction of cereblon-based PROTACs
Based on this assumption, several studies evaluated the efficacy of pharmacological compounds modulating key neurotransmitter systems, including glutamatergic, GABAergic, dopaminergic, serotonergic, and cholinergic signaling, to alleviate ASD-like phenotypes
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Reversible Opening of the Blood-Brain Barrier by Claudin-5-Binding Variants of Clostridium Perfringens Enterotoxins Claudin-Binding Domain
