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Uncoupling high light responses from singlet oxygen retrograde signaling and spatial-temporal systemic acquired acclimation

GPX4 is the only enzyme capable of directly detoxifying lipid peroxides, and its activity requires GSH as a cofactor[61, 64]

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(116) observed that individuals with HLA-DR2 (HLA-DR15 and HLA-DR16) showed significantly increased antiviral antibody titers (herpes simplex type 1, cytomegalovirus, EBV and rubella virus) compared to individuals with other HLA-DR types

There are three HO isoforms (HO-1, HO-2, HO-3) that have been described (Siow et al., 1999), although HO-3 may be a pseudogene derived from HO-2 transcripts (Hayashi et al., Figure 1 Cumulative evidence has shown that expression of HO-1 in the vasculature exerts protective effects against vascular inflammatory processes, thanks to its antioxidant, antiinflammatory, antiapoptotic, and possibly immunomodulatory properties