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These mice were handled daily, and their body weight and food intake were measured every morning at 9:00 A

To distinguish the roles of GHS-R in neurons from peripheral tissues, we generated a conditional knockout mouse line using neuron-specific driver of Synapsin-cre

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Neurological features of Menkes disease can include seizures, hypotonia, severe developmental delay, and brain atrophy, which unfortunately contribute to death by 3 years of age (Kaler, 2013
