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In gastrointestinal lesions (indomethacin (30 mg/kg s.c.), aspirin (400 mg/kg i.g.) and diclofenac (125 mg/kg i.p.)) studies, NaBPC157 (10 g or 10 ng/kg i.p.) was given regularly, either simultaneously and/or one hour prior to drug application (indomethacin)

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The FIDELITY analysis (2024) of the FIDELIO-DKD and FIGARO-DKD trials reported a 19% reduction in combined kidney and cardiovascular outcomes in T2DM patients, with a lower incidence of DR progression in the finerenone group compared to placebo (142)

XRD patterns were acquired using a Rigaku RU-200b X-ray diffractometer with Cu K radiation ( = 1.5418 )

Increased reactive oxygen species are a hallmark feature of the pathogenesis of multiple cardiometabolic diseases, including atherosclerosis, diabetes, fatty liver and CVD