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Numbness, tingling, or a pins-and-needles sensation

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

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doi: 10.1161/ATVBAHA.111.241893

This hints at the peptide's potential to combat muscle atrophy under specific circumstances