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Such biomarkers include zonulin, fatty acid binding proteins (FABP), citrulline, glucagon-like peptide (GLP)-2, LPS, LPS-binding protein (LBP) or fecal 1 antitrypsin (AAT), for example

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Safety research is mostly from adults

As research continues, larger-scale human trials are needed to establish definitive clinical protocols and safety profiles

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Researchers are encouraged to identify whether the subclinical deficiency or deficiency itself of this vitamin is a risk factor for COVID-19 complications, and it is necessary to carry out intervention studies with vitamin B 12 supplementation in both the adjuvant treatment of mild, moderate, and severe COVID-19 and postCOVID-19, with a focus on minimizing symptoms related to the musclegutbrain axis