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Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice

The addition of L-carnitine to the normal energy diet reduced the pH of the egg yolk, while it increased egg yolk pH when added to the low energy diet

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Metabolic changes included reduced indole, increased levels of in pipecolic acid, the methyl group donor SAM (S-Adenosylmethionine), and trigonelline (131)

Sigma-Aldrich) conditions for 3 days (for MCECs) or 5 days for major pelvic ganglia (MPG), dorsal root ganglia (DRG), and aortic rings maintained at 37 C in a humidified environment with 5% CO 2 25