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The skin is the largest organ in the human body, comprising up to 16 percent of total body weight (83)

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On the other hand, post-translational modifications of the repair proteins themselves, such as phosphorylation and acetylation, precisely control their localization, activity and function, forming the dynamic regulatory core of the repair network (11)

Melatonin has been reported to be involved in the induction of G6PD enzymatic activity to protect the cell from oxidative damage.41,42 Besides, melatonin also attenuates the enzymatic activity of nitric oxide synthetase (NOS) and production of NO that provides the further protection from NO mediated production of more potent oxidant peroxynitrite specie (ONOO).43 Therefore, melatonin mediates the multifaceted stimulation of antioxidant enzymes and enhance the cellular protection against oxidative stress