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Of course, there are many other people who have decided that the discomfort and discipline of either calorie restriction or exercise are too high a price for the (substantial) improvement in health or the (modest) increase in life expectancy

Drenning JA, Lira VA, Soltow QA, Canon CN, Valera LM, Brown DL, Criswell DS

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Mol Gen Genomics 272:639650 Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DeltaC(T)) method