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Subsequent research indicated that the enhancement of MET by activating UPF1 (a versatile RNA and DNA helicase) caused phosphorylation, which, in turn, controlled the 3'-UTR length of STING, leading to a decrease in STING expression in cancer cells [123]

Meanwhile, 2OGDH in RLM has lower protein levels (30%) than RHM and HepM

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Michelet L, Zaffagnini M, Massot V, Keryer E, Vanacker H, Miginiac-Maslow M, et al

When T cells recognize pathogens through T-cell receptors, together with costimulatory signals provided by antigen-presenting cells, T cells expand clonally and traffic to tissues, thereby triggering an adaptive immune response

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