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Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

Physiol Rev 99: 2178, 2019

The hydrophobic staple motif consists of a specific i,i+5 hydrophobic interaction between a residue (N) that precedes the N-cap residue and a residue (N4) located within the 6-helix

Remember it took me a year of treatment to get my manganese levels down enough just to achieve the first signs of remission

[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Shaughnessy D.T., McAllister K., Worth L., Haugen A.C., Meyer J.N., Domann F.E., Houten B.V., Mostoslavsky R., Bultman S.J., Baccarelli A.A., et al

In the cytosol, aberrant IRP1 activation increases the labile iron pool through enhanced transferrin-mediated iron import and NCOA4-mediated ferritinophagy