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A lack of integration also plays a role, with poor screening for substance use disorders in both mental health and primary care settings, along with significant provider shortages in rural areas

This reduces the systemic inflammatory load that ultimately reaches the brain and activates neuroinflammatory pathways driving anxiety
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Table 4 : Recommendations for oral vitamin B12 treatment [ 23,26 ]

Vitamin E: Subtle Yet Significant Anticoagulant Interaction High-dose vitamin E may increase bleeding when combined with medications like aspirin or warfarin