glutathione synthesis and oxidative stress Early After Hematopoietic Stem Cell Transplant Figure 1 from Dossier :
Description
PMC 4471173

Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

Ivanova Stojcheva, E., & Quintela, J

Hadian K, Stockwell BR

So the risk of taking excessively high doses of B12 is mitigated as long as your kidneys are working (which is the case for many of you)

While rare, early identification and intervention can significantly improve outcomes and prevent symptom progression