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Medical mycology, 57(Supplement_2), S189S195

The CPT1A inhibitor etomoxir can affect and coordinate with the conventional chemotherapy drug cisplatin to increase tumor cell sensitivity to the chemotherapeutic agent, inhibit tumor cell proliferation and promote apoptosis, thus providing a novel approach to improving the efficacy of chemotherapy in non-small cell lung cancer ( CPT1A in glioblastoma multiforme (GBM) GBM is the most common and difficult central nervous system malignancies, with a 5-year survival rate of 6.8% ( CPT1A in colon cancer Colon cancer develops in adipose-rich microenvironment, and CPT1A overexpression is crucial for adipocytes to promote tumor growth in colon cancer (Wen et al., 2017

Endpoints: Indirect calorimetry (RER, substrate oxidation), time-to-exhaustion/work tests, biopsy-based carnitine pools (free/acetylcarnitine), AR protein content, and recovery biomarkers