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Moreover, the core protein increased calcium influx, and reduced electron transport chain complex I activity and consequent ROS production [245]
The long-term consequences of chronically elevating MOTS-c levels beyond physiological norms are not yet known
Earlier framings of "0.34 partial agonist at GCGR" or "0.4 softened agonist at GLP-1R" mistook potency ratios (EC50_LY EC50_native) for efficacy multipliers (E_max_LY E_max_native) and are retracted
Voehringer DW, Meyn RE
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Davis Lecture at the 2023 Fatigatio Symposium
