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Additionally, multiple immune-related pathways were activated via lipid peroxidation, such as TLR4, AGER and STING1 pathways (Fig

Furthermore, catalase supplementation reduced airway hyper responsiveness after viral inoculation

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120 ROS play crucial modulatory roles in amplifying distal TCR pathways, including Ca 2+ -calcineurin-NFAT, IKK-NF-B, Ras-ERK1/2, and mTOR cascades, which in turn enhance T-cell activation, proliferation, and cytokine production (e.g., IL-2)

M.HeB.KaragiannisD.LiY.JiangH.SrinivasanP.et al (2023)

doi: 10.1016/j.jtemb.2006.03.002