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Therefore, the development of new therapeutic drugs is urgently needed

People with low glutathione levels or those with less efficient detoxification genes are at a higher risk of developing the associated diseases

Therefore, L-serine supplementation has been suggested as a rational therapeutical approach in several disorders, particularly primary disorders of L-serine synthesis, neurodegenerative disorders, and diabetic neuropathy

doi: 10.1101/2024.01.30.578087

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Simultaneously, the SAPK/JNK pathway can suppress ferroportin expression, limiting the efflux of intracellular iron and further contributing to iron accumulation, thus promoting ferroptosis [129, 130]