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In the first case, this is due to the fact that NEM does not react with GSH under acidic conditions

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T & Masmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders

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Interestingly, in contrast to ChEIs, memantine, which antagonizes NMDA receptors, attenuated antipsychotic-induced EPS ( Figure 6 )