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Under conditions of fasting, hepatic metabolism is shunted toward gluconeogenesis, making fewer glucose precursors available for glucuronidation

Eur J Pharmacol 912:174617

PMID 19289127

When the body's reserves of this crucial compound are depleteda phenomenon heavily documented in both Long COVID and ME/CFSthe resulting cellular damage can drive profound fatigue, brain fog, and immune dysfunction

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen