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SARS-CoV-2 influences intracellular GSH levels by decreasing the function of intracellular NRF2, which plays an important role in protecting cells from oxidative damage by upregulating GSH production (Figure 1)

Correspondingly, ZD results in developmental retardation of children, delayed genital development and hypogonadism, skin disorders, hair loss, teratogenic effects, as well as weakened immune function, leading to an increased susceptibility to infections

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Key genes in the melatonin biosynthesis pathway with circadian rhythm are associated with various abiotic stresses
