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The spatial extent of the regions occupied by cells displaying these distinct metabolic phenotypes is large enough to be detected using clinically applicable metabolic imaging techniques

The de novo synthesis pathway (e.g., serine synthesis pathway, SSP) confers metabolic autonomy by enabling endogenous serine production, particularly under nutrient-replete conditions where SSP suffices to meet proliferative demands ( Metabolic plasticity serves as a hallmark of cancer cell adaptation to microenvironmental heterogeneity

It was found that THC-SLNs gel showed a significantly higher drug release and better ( p 0.001) activity in comparison to free THC

-Amylases are calcium-dependent metalloenzymes that act randomly on the starchy substrates yielding maltose and maltotriose from amylose or glucose and dextrin from amylopectin [87]

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Zhao S, Mi Y, Guan B, Zheng B, Wei P, Gu Y, Zhang Z et al (2020) Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer