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WangXYangCGuoFZhangYJuZJiangQet al

Gonzlez-Aramburu I, Snchez-Juan P, Sierra M, et al

BioMed Pharmacother (2021) 134:111125

For instance, aprotinin is a well-known serine protease inhibitor that has been co-formulated with insulin in thiolated chitosan xerogels, leading to a 70% reduction in enzymatic degradation and a 1.7-fold increase in insulin permeability across human EpiOral models and ex vivo sheep buccal mucosa [101]
