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Busulfan is a bifunctional alkylating agent used for the treatment of hematologic and other malignancies prior to stem cell transplantation (e.g., Iwamoto et al., 2004)

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J Immunol Methods (2015) 425:1020

Excessive activation could theoretically lower seizure thresholds, promote excitotoxicity, or disrupt the balance between excitatory and inhibitory neurotransmission

PMID: 27420634