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HO-1 is a key mediator of ferroptosis and plays an important role in the development of various diseases (Lei et al., 2019)

Glutathione is a tripeptide molecule composed of three amino acids: L-glutamine, L-cysteine, and L-glycine

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However, excess vitamin B12 in the body can cause histamine intolerance symptoms

Moreover, increased oxidative stress suppresses the expression of long-chain acyl-CoA synthetase-1, the key enzyme in fatty acid oxidation by mitochondria, ultimately leading to renal lipid accumulation in renal tubules and accelerating the development of obesity-related nephropathy [170,171]

Doxycycline (5 mg/kg/day) also reduces the severity of disease in dogs that experimentally infected with an extremely pathogenic isolate of B