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doi: 10.1097/WON.0000000000000703

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doi: 10.1158/1541-7786.MCR-05-0221 264 HardingHPNovoaIZhangYZengHWekRSchapiraMet al

Moreover, the treatment should be able to reach the central nervous system, which is a difficulty for both drugs (must cross the bloodbrain barrier or be administered intrathecally) [263] and devices (surgical access to the CNS might be required)