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GH then acts directly on tissues and indirectly through hepatic production of insulin-like growth factor 1 (IGF-1), which mediates many of GHs anabolic effects

Maheshwari A, Verma N, Swaroop A, Bagchi M, Preuss HG, Tiwari K, et al

used the synthetic peptides GHRP-1, GHRP-2, GHRP-4, GHRP-5, GHRP-6, alexamorelin, hexarelin, ipamorelin, N-acetyl-LKKTETQ (TB-500), and desmopressin to study the metabolism of in vitro models

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Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA

(3) Disruption of the bidirectional gut-brain axis: MPs/NPs compromise intestinal barrier integrity by downregulating key tight junction proteins like ZO-1 and occludin, induce dysbiosis (elevated F/B ratio, reduced SCFA), and facilitate systemic translocation of endotoxins