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Imatinib-induced GPX4 proteasomal degradation Imatinib is a tyrosine kinase inhibitor designed to inhibit BCR-ABL activity in chronic myelogenous leukemia (CML) that revolutionized the treatment of this hematopoietic malignancy in the early 2000s [46]

In contrast, the esiRNA against ALK7 significantly reduced ALK5 mRNA expression in aSyn-overexpressing cells (Fig

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