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These parameters include stability of biological fluids, biodegradability, favorable pharmacokinetic properties, adequate release profiles, non-toxicity, biocompatibility, and good drug loading efficiency [219, 220]

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Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results