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Tumor redox heterogeneity, variations in intracellular GSH levels, and discrepancies between in vitro and in vivo redox environments make precise prediction of therapeutic activation difficult

doi: 10.1016/j.bcp.2023.115417 93 XiaoPLiMZhouMZhaoXWangCQiuJet al

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Elevated levels of GSH are critical for the optimal function of GPx that utilizes GSH as a substrate to neutralize H 2 O 2 and lipid hydroperoxides (41)

The expression of the cystine/glutamate transporter is induced in the context of high oxidative stress and cell proliferation, ,, and its inhibition hinders glutathione synthesis leading to ferroptosis