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Insights into the metabolic regulation of T cells offer potential therapeutic strategies to manipulate T cell function, with implications for treating autoimmune diseases, chronic inflammation, and cancer by targeting specific metabolic pathways

Nitschke, W

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While formal clinical trials of this specific combination await development, the theoretical basis for synergy is compelling, supported by successful precedents like CagriSema and the impressive individual performance of both compounds

Also, in agreement with the non-apoptotic, caspase-independent nature of ferroptosis, we found that persister cell death from GPX4 inhibition is not rescued by the pan-caspase inhibitor Z-VAD-FMK (Fig

Research suggests that curcumin-induced inactivation of GSTP1 leads to the activation of nuclear factor-B (NF-B) and subsequent anti-cancer effects in treated cells