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Indole-3-carbinol (I3C) and its metabolite DIM exert hormone-modulatory effects by shifting estrogen metabolism from the genotoxic 16-hydroxyestrone pathway toward the less carcinogenic 2-hydroxyestrone pathway, enhancing CYP1A1/1A2 activity, and simultaneously downregulating ER and upregulating ER expression, which together lead to suppression of estrogen-driven proliferation and sensitization of tumours to endocrine therapies (191)

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The study also revealed a decreased number of acetylated LDL and ulex lectin double-positive cells after pCRP treatment [95]

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The left atrial:aortic root ratio and LVIDs were also significantly decreased from baseline in most patients (n = 22 and n = 23, respectively)

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A variety of genetic and environmental factors likely contribute to this complex condition

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If the health-care system fails to meet the needs of patients, people will look for their own solutions

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