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Immunological reviews

Yes, foods with artificial dyes can change urine color

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4- fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2- azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

However, the amount is extremely small and is not considered harmful
The hypothalamus and pituitary gland also regulates thyroid hormone production, so that slows down as well
