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Recently a novel covalent inhibitor EN25 and its derivatives targeting GCLM subunit were discovered through covalent library screening, with a reported IC 50 of 16 M in 15 min reaction for EN25 and 6.8 M for the most potent derivative EN258 [71]
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A phase I, randomized, SAD, MAD, and PK study of Risvodetinib in older adults and Parkinsons disease
