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Glutathione peroxidases Five selenium-containing glutathione peroxidases (GPx1-4 and GPx6) have been identified: GPx1 (cytosolic GPx), GPx2 (epithelial cell-specific GPx first identified in intestinal lining and lungs), GPx3 (highly expressed in thyroid gland and kidneys), GPx4 (phospholipid-hydroperoxide GPx

however, organ damage during MTX treatment reduces its therapeutic effectiveness (Reference Shinde, Venkatesh and Kumar32)

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doi: 10.1016/j.phytochem.2022.113451

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Fernndez-Lzaro D et al