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First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

10.1186/s13041-014-0088-4 17 BedoukianM

Noteworthy, it has been demonstrated that acetaminophen, another type of commonly used nonopioid medication, toxicity can contribute to some opioid-related mortality [105]

these changes may be a sign of degradation or contamination

Cell Tissue Res 252(1):7987 Pompolo S, Furness JB (1988) Ultrastructure and synaptic relationships of calbindin-reactive, Dogiel type II neurons, in myenteric ganglia of guinea-pig small intestine