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doi:10.1002/lary.26607

Antioxidant Protection: Glutathione helps to protect the skin from oxidative damage that can accelerate aging

Fatty synthase (FASN) is important for palmitate synthesis and this enzymes expression is elevated in many tumors

In addition, NF-B may promote RIPK1 translocation to the mitochondria where it forms a complex with PINK1 and phosphoglycerate mutase family member 5 (PGAM5) that stabilizes and activates PINK1, eventually inducing mitophagy 122

These interventions should be individualized and biomarker-guided (e.g., endothelial function, Prx redox state, GSH/GSSG, F 2 -isoprostanes, LIP assays) and titrated to preserve beneficial H 2 O 2 -based signalling while preventing convergence onto ONOO , hydroxyl-radical formation and runaway lipid peroxidation (Frijhoff et al

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