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Description
It is a quinolinium derivative with a molecular weight of only 194.66 g/mol, making it much smaller than peptides

Moreover, GSH stores are consumed in animals subjected to experimental cholestasis or in hepatocytes exposed to toxic bile acids [184,185]

A., Ferreira, S

The K d value of PGRMC1 binding to CYP51 was in a micromolar range and comparable with those of other haem proteins, such as cytochrome P450 reductase 35 and neuroglobin/ G i1 (ref

Mansur DB

This creates a vicious cycle wherein oxidative stress further activates CYP2E1, aggravating lipid peroxidation, hepatocyte injury, and inflammation